Klf4 atherosclerosis

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August undefined, 2024

WebMar 1, 2024 · Atherosclerosis is an important problem in modern medicine, the keys to understanding many aspects of which are still not available to clinicians. ... The large family of KLFs in humans includes 18 members, among which KLF2 and KLF4 are at the crossroads between endothelial cell mechanobiology and immunometabolism, which play … WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs.

Converting smooth muscle cells to macrophage-like cells with KLF4 …

WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebMay 24, 2024 · The KLF4 gene is itself a CAD GWAS risk allele with the putative variant (rs944172) located ≈265 kb upstream of the KLF4 transcription start site. The nature of this variant is unclear; however, it overlaps a weak AP1 binding site with some evidence for … dead birds 2022

Frontiers C1q/TNF-Related Protein 9 Attenuates Atherosclerosis …

WebRationale for Study: MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein expression at post-transcriptional level. We hypothesized that a specific pool of endothelial miRNAs could be selectively regulated by flow conditions and WebJan 1, 2008 · Herein we hypothesize that KLF4 is an important regulator in different phase of atherosclerosis and may be a novel target of prevention and cure of atherosclerosis. Further investigation is needed to approach the concrete signaling pathways about KLF4. WebJan 11, 2024 · Notably, “Atherosclerosis Signaling” was the top pathway associated with the gene expression pattern in Klf4-deleted CD11b + myeloid cells isolated from Hi-Myc tumors. Atherosclerosis is a progressive disease that narrows the vascular lumen through a buildup of arterial plaque, an amalgam of lipids, macrophages and other leukocytes, smooth ... dead birds 2021

JCI - Endothelial Kruppel-like factor 4 protects against ...

Abstract 294: Mir34a is a Key Regulator Linking Liver and …

WebFeb 8, 2024 · KLF4 promotes phenotypic modulation into macrophage-like and Sca1-expressing mesenchymal-like VSMCs, while MSCs differentiate into VSMCs in vitro when exposed to TGFβ and PDGF-BB. VSMCs might also derive from ECs following EndMT driven by TGFβ signalling. dead birds around houseWebDec 5, 2024 · Our study indicates that KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions, suggesting that a previously unrecognized KLF4-eEF1A2/circCTDP1-PFKFB3 axis plays... dead birds 2018

"WebDec 13, 2024 · KLF4 is a zinc-finger-containing transcription factor that plays a crucial role in maintaining cell senescence in response to cellular stress. Studies have shown that KLF4 typically upregulates p21 to promote cell growth arrest ( Chew et al., 2011 ). " - Klf4 atherosclerosis

Klf4 atherosclerosis

Formononetin attenuates atherosclerosis via regulating …

WebMar 29, 2024 · CSC increased the expression of inflammatory markers and reduced the contractile ones in both cell types, with KLF4 modulating the SMC phenotypic switch. Next, we performed a mass spectrometry-based differential proteomic approach on human SMCs and could show 11 proteins were significantly affected by exposition to CSC (FC ≥ 2.7, p ≤ … WebFurthermore, Klf4 has been identified as an anti-proliferative shear stress-responsive gene, and forced over-expression of Klf4 in VSMCs induces growth arrest. Klf4 may therefore be an important protective factor in disease states affected by shear stress, such as thrombosis, restenosis and atherosclerosis.

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WebNov 19, 2012 · Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis. Using in vivo EC-specific KLF4 overexpression and knockdown murine models, we found that KLF4 induced an antiadhesive, antithrombotic … WebApr 7, 2024 · Background Although inflammatory cell adhesion molecules (CAMs) and anti-inflammation factor Kruppel-like transcription factor (KLF) 4 have all been reported to be induced after cerebral ischemic stroke (CIS), the close temporal and spatial relationship …

WebApr 21, 2024 · Laminar, but not disturbed flow, induces expression of the extracellular matrix protein TN-X (tenascin-X) in mouse and human endothelial cells through the transcription factor KLF4 (Krüppel-like factor … WebJun 11, 2024 · In addition, a pivotal contribution of KLF4-dependent regulation of macrophage function to cardiovascular disease is exemplified by the observation that myeloid Klf4 deficiency augments vascular inflammation and atherosclerotic lesion formation in Apoe −/− mice . A surprising function of KLF4 in atherosclerosis was also …

WebDec 1, 2014 · Blockade of mir-92a restores Klf2 and Klf4 expression, reduces endothelial inflammation and monocyte infiltration, thereby limiting atherosclerosis. 19 Disturbed flow and other proatherogenic factors also downregulate the endothelial expression of negative guidance cues, particularly Netrin-1 and Semaphorin3A, while upregulating EphrinB2, and … WebJun 29, 2024 · In macrophages, miR-34a regulated M1 and M2 macrophage polarization as well as cholesterol efflux via liver X receptor å (LXRå) and Kruppel-like factor 4 (KLF4). Consistent with these findings, macrophage-selective or global ablation of miR-34a markedly inhibited the development of atherosclerosis in Ldlr-/-mice or Apoe-/-mice. Finally ...

WebMay 18, 2015 · On the basis of in vivo KLF4 chromatin immunoprecipitation–sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many...

WebAtherosclerosis, the leading cause of death, is a vascular disease of... dead birds 2005WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs. dead birds and wind turbinesWebJan 1, 2024 · These results indicate that formononetin may regulate KLF4 expression during atherosclerosis development. Given the role of KLF4 and SRA in atherogenesis, we postulate that formononetin may be antiatherogenic, in part, through regulation of KLF4-SRA … gem of trapped innocentsWebNov 26, 2024 · In this mechanism induced by oxidized low-density lipoprotein (oxLDL), the KLF4 factor suppresses the expression of VSMC genes (SM22α, ACTA2, MYH11) by binding to the G/C repressor element in the gene promoter and by inhibiting the binding of transcription factors to the CArG element mechanism, leading to phenotypic switching ( … gem of thronsWebOct 3, 2024 · Conclusions: KLF4 transactivates Ch25h and LXR, thereby promoting the synergistic effects between ECs and macrophages to protect against atherosclerosis susceptibility. Keywords: atherosclerosis; cholesterol; endothelial cells; inflammation; … dead birds artWebAtherosclerosis, the leading cause of death, is a vascular disease of... gem of the worldWebOct 11, 2012 · In summary, our observations implicate myeloid KLF4 as a key regulator of experimental atherogenesis in mice. The fact that KLF4 has been shown to confer favorable anti-inflammatory effects in both the … gemography salaries in egypt