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The sox2 transcription factor binds rna

WebMar 2, 2024 · INTRODUCTION. Essential cellular processes such as replication, recombination, and DNA repair occur alongside transcription on DNA. During transcription, RNA polymerase II (RNAPII) pauses at discrete sites, which in some instances is required for proper regulation of gene expression (1, 2).Prolonged pausing and/or stalling of the … WebMar 13, 2024 · We report the unprecedented finding that the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia.

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WebSeveral recent studies have revealed that the Sox2 transcription factor binds RNA through its high-mobility group box (HMGB) domain in vitro and in vivo. A high degree of … WebApr 10, 2024 · The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this … blender ループカット https://the-traf.com

SOX2 transcription factor binding and function

WebHolmes, Z. E., Hamilton, D. J., Hwang, T., Parsonnet, N. V., Rinn, J. L., Wuttke, D. S., & Batey, R. T. (2024). The Sox2 transcription factor binds RNA. WebJan 1, 2003 · The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression. We have used gene targeting to inactivate Sox2, examining the phenotypic consequences in mutant embryos and in chimeras in which the epiblast is rescued with wild-type ES cells. We find a cell-autonomous requirement for the gene in both epiblast and ... WebSox2 (SRY-box containing gene 2) lies at the center of these programs (Avilion et al., 2003; Takahashi and Yamanaka, 2006). Sox2 binds to DNA via its highly conserved HMG-box domain, often in co-operation with other transcription factors … blender レンダー 背景 白

The DNA-Binding High-Mobility Group Box Domain of Sox …

Category:SOX2 SRY-box transcription factor 2 [ (human)] - National Center …

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The sox2 transcription factor binds rna

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WebApr 14, 2024 · SOX2 can bind directly to ES2 lncRNA with high affinity through its DNA-binding HMG domain [144]. Numerous studies have reported aberrant expression of SOX2 … WebApr 14, 2024 · Europe PMC is an archive of life sciences journal literature.

The sox2 transcription factor binds rna

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WebSox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly …

WebMar 1, 2024 · Transcription factor Mode of Sox2 expression regulation Mechanism of action Function(s) Expression in breast cancer Cell line used Ref. DACH1: Negative: Binds to Sox2 promoter, repressing its transcription, possibly via HDAC1 recruitment: Cell fate determination, maintenance of stemness in breast tumor stem cell: Downregulated: Basal … WebSOX2 is required for multiple steps in formation of the trachea, lung, and esophagus. During these processes, SOX2 is complementarily expressed with other transcription factors, for …

WebJul 21, 2024 · ABSTRACT. The transcription factor SOX2 is a vital regulator of stem cell activity in various developing and adult tissues. Mounting evidence has demonstrated the … WebJun 25, 2012 · The mitochondrial transcription factor A (mtTFA) is central to assembly and initiation of the mitochondrial transcription complex. Human mtTFA (h-mtTFA) is a dual high mobility group box (HMGB) protein that binds site-specifically to the mitochondrial genome and demarcates the promoters for recruitment of h-mtTFB1, h-mtTFB2 and the ...

WebApr 10, 2024 · p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma. Long non-coding RNA …

WebMay 31, 2024 · Transcription factors are proteins that bind to specific DNA sequences and control the rate at which genes are transcribed to produce messenger RNA [46]. 和英語林集成 コトバンクWebSox1ot and Sox2ot are highly expressed during neural development and are directly proportional to the Sox1 and Sox2 transcription factors abundance respectively [55,82] overlapping transcript ... 和英翻訳 サイトWebApr 14, 2024 · Since SOX2 was reported to directly bind to the upstream regulatory region of human papillomavirus E6 to ... To identify genes regulated by SOX2, RNA sequencing (RNA-Seq) was performed in SOX2-OE and Ctl U251 cells. ... Ma YX, Ying MY et al. Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive … 和菓子のアン シリーズ 順番WebAug 8, 2014 · Background The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripotent cells. Although generally studied as a transcriptional activator, recent evidence suggests that it might also repress … blender レンダリング 圧縮WebNov 26, 2024 · SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple tran … 和英 舵を切るWebJul 15, 2024 · Abstract. The transcription factor SOX2 is a vital regulator of stem cell activity in various developing and adult tissues. Mounting evidence has demonstrated the … 和菓子 イラスト 無料WebDownloadable! Certain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor … 和菓子 イラストや