WebMar 2, 2024 · INTRODUCTION. Essential cellular processes such as replication, recombination, and DNA repair occur alongside transcription on DNA. During transcription, RNA polymerase II (RNAPII) pauses at discrete sites, which in some instances is required for proper regulation of gene expression (1, 2).Prolonged pausing and/or stalling of the … WebMar 13, 2024 · We report the unprecedented finding that the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia.
The RNA interactome in the Hallmarks of Cancer - Gabryelska - WIREs RNA …
WebSeveral recent studies have revealed that the Sox2 transcription factor binds RNA through its high-mobility group box (HMGB) domain in vitro and in vivo. A high degree of … WebApr 10, 2024 · The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this … blender ループカット
SOX2 transcription factor binding and function
WebHolmes, Z. E., Hamilton, D. J., Hwang, T., Parsonnet, N. V., Rinn, J. L., Wuttke, D. S., & Batey, R. T. (2024). The Sox2 transcription factor binds RNA. WebJan 1, 2003 · The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression. We have used gene targeting to inactivate Sox2, examining the phenotypic consequences in mutant embryos and in chimeras in which the epiblast is rescued with wild-type ES cells. We find a cell-autonomous requirement for the gene in both epiblast and ... WebSox2 (SRY-box containing gene 2) lies at the center of these programs (Avilion et al., 2003; Takahashi and Yamanaka, 2006). Sox2 binds to DNA via its highly conserved HMG-box domain, often in co-operation with other transcription factors … blender レンダー 背景 白